Sildenafil

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Sildenafil
Sildenafil structure.svg
Sildenafil-from-xtal-3D-balls.png
Clinical data
Pronunciation /sɪlˈdɛnəfɪl/ sil-DEN-ə-fil
Trade names Viagra, Revatio, others
AHFS/Drugs.com Monograph
MedlinePlus a699015
data
Pregnancy
category
Routes of
administration
By mouth (tablets), intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 41% (mean)[7]
Protein binding ~96%
Metabolism Liver: CYP3A4 (major route), CYP2C9 (minor route)
Metabolites N-desmethylsildenafil (~50% potency for PDE5)
Onset of action 20 minutes
Elimination half-life 3–4 hours
Excretion Feces (~80%), urine (~13%)[6]
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
ECHA InfoCard 100.122.676 Edit this at Wikidata
Chemical and physical data
Formula C22H30N6O4S
Molar mass 474.58 g·mol−1
3D model (JSmol)
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Sildenafil (ing-gú: Sildenafil, Viagra; hàn-gú: 西地那非, 威而鋼) sī iōng Viagra tíng-tíng ê phín-pâi lâi siau-siū, sī tsı̽t-tsióng iōng-teh tī-liâu khí-pu̍t kong-lêng chiòng-gāi [en] hām Hì tōng-me̍h ko-ap [en] ê io̽h-bu̽t.[6][8] Bo̽k-tsiân koh bô-tshing-tshó Sildenafil m̄-tsai tuì tī-liâu lú-sìng sìng-kong-lîng ê tsiong-ài kám ū-hāu.[8] kháu-hok hi̍k-tsiá tsīng-me̽h tsù-siā [en].[8] İo̽h-hāu khai-sí tsok-iōng thong-siông teh 20 hun-tsing tsi-lāi, ē-tàng tshî-siok tòng-kàu 2 tiám-tsing kú.[8]

Tsù-kái[siu-kái | kái goân-sí-bé]

  1. "Sildenafil Use During Pregnancy". Drugs.com. 7 October 2019. 6 October 2020 khòaⁿ--ê. 
  2. "Viagra EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê. 
  3. "Revatio EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê. 
  4. "Viagra 25mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 7 August 2020. 6 October 2020 khòaⁿ--ê. 
  5. "Viagra Connect 50 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 5 December 2017. 6 October 2020 khòaⁿ--ê. 
  6. 6.0 6.1 6.2 "Viagra- sildenafil citrate tablet, film coated". DailyMed. 6 October 2020 khòaⁿ--ê. 
  7. Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". British Journal of Clinical Pharmacology. 53 (Suppl 1): 5S–12S. doi:10.1046/j.0306-5251.2001.00027.x. PMC 1874258Freely accessible. PMID 11879254. 
  8. 8.0 8.1 8.2 8.3 "Sildenafil Citrate". The American Society of Health-System Pharmacists. 1 December 2014 khòaⁿ--ê. 

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