Sildenafil

Sildenafil
Clinical data
Pronunciation	/sɪlˈdɛnəfɪl/ sil-DEN-ə-fil
Trade names	Viagra, Revatio, others
AHFS/Drugs.com	Monograph
MedlinePlus	a699015
data	EU EMA: by INN; US FDA: Sildenafil;
Pregnancy; category	AU: B1 ; ;
Routes of; administration	By mouth (tablets), intravenous
ATC code	G04BE03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: over-the-counter (OTC) / P; US: ℞-only ; EU: Rx-only ; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	41% (mean)
Protein binding	~96%
Metabolism	Liver: CYP3A4 (major route), CYP2C9 (minor route)
Metabolites	N-desmethylsildenafil (~50% potency for PDE5)
Onset of action	20 minutes
Elimination half-life	3–4 hours
Excretion	Feces (~80%), urine (~13%)
Identifiers
	IUPAC name 5-{2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;
CAS Number	139755-83-2 ; citrate: 171599-83-0 ;
PubChem CID	135398744; citrate: 135413523;
DrugBank	DB00203 ; citrate: DBSALT000347 ;
ChemSpider	5023 ; citrate: 56586 ;
UNII	3M7OB98Y7H; citrate: BW9B0ZE037 ;
KEGG	D08514 ; citrate: D02229 ;
ChEBI	CHEBI:9139 ; citrate: CHEBI:58987 ;
ChEMBL	CHEMBL192 ; citrate: CHEMBL1737 ;
PDB ligand	VIA (PDBe, RCSB PDB);
ECHA InfoCard	100.122.676
Chemical and physical data
Formula	C22H30N6O4S
Molar mass	474.58 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C;
	InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) ; Key:BNRNXUUZRGQAQC-UHFFFAOYSA-N ;
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Sildenafil (ing-gú: Sildenafil, Viagra; hàn-gú: 西地那非, 威而鋼) sī iōng Viagra tíng-tíng ê phín-pâi lâi siau-siū, sī tsı̽t-tsióng iōng-teh tī-liâu khí-pu̍t kong-lêng chiòng-gāi [en] hām Hì tōng-me̍h ko-ap [en] ê io̽h-bu̽t.^[6]^[8] Bo̽k-tsiân koh bô-tshing-tshó Sildenafil m̄-tsai tuì tī-liâu lú-sìng sìng-kong-lîng ê tsiong-ài kám ū-hāu.^[8] kháu-hok hi̍k-tsiá tsīng-me̽h tsù-siā [en].^[8] İo̽h-hāu khai-sí tsok-iōng thong-siông teh 20 hun-tsing tsi-lāi, ē-tàng tshî-siok tòng-kàu 2 tiám-tsing kú.^[8]

Tsù-kái

↑ "Sildenafil Use During Pregnancy". Drugs.com. 7 October 2019. 6 October 2020 khòaⁿ--ê.
↑ "Viagra EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê.
↑ "Revatio EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê.
↑ "Viagra 25mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 7 August 2020. 6 October 2020 khòaⁿ--ê.
↑ "Viagra Connect 50 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 5 December 2017. 6 October 2020 khòaⁿ--ê.
↑ ^6.0 ^6.1 ^6.2 "Viagra- sildenafil citrate tablet, film coated". DailyMed. 6 October 2020 khòaⁿ--ê.
↑ Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". British Journal of Clinical Pharmacology. 53 (Suppl 1): 5S–12S. doi:10.1046/j.0306-5251.2001.00027.x. PMC 1874258 . PMID 11879254.
↑ ^8.0 ^8.1 ^8.2 ^8.3 "Sildenafil Citrate". The American Society of Health-System Pharmacists. 1 December 2014 khòaⁿ--ê.

Tsham-ua̽t

Basmanny su-hoat [ru] (Basmanny su-huat/Басманное правосудие)
Lietuva Pōo-tshìng-ping Liân-bîng [en] (Lithuanian Riflemen's Union)
James Mason (sin-Nazi) [en] (James Mason (neo-Nazi))
Ukraina kau-thong [en]
Aelia Eudocia [en]

Guā-pōo lên-ket

"Sildenafil". Drug Information Portal. U.S. National Library of Medicine. (Eng-gí)
"Sildenafil citrate". Drug Information Portal. U.S. National Library of Medicine. (Eng-gí)
Viagra at The Periodic Table of Videos (University of Nottingham) (Eng-gí)

[Drugs.com_pregnancy-1] "Sildenafil Use During Pregnancy". Drugs.com. 7 October 2019. 6 October 2020 khòaⁿ--ê.

[Viagra_EPAR-2] "Viagra EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê.

[Revatio_EPAR-3] "Revatio EPAR". European Medicines Agency. 6 October 2020 khòaⁿ--ê.

[4] "Viagra 25mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 7 August 2020. 6 October 2020 khòaⁿ--ê.

[5] "Viagra Connect 50 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 5 December 2017. 6 October 2020 khòaⁿ--ê.

[Viagra_FDA_label-6] 6.0 ^6.1 ^6.2 "Viagra- sildenafil citrate tablet, film coated". DailyMed. 6 October 2020 khòaⁿ--ê.

[7] Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". British Journal of Clinical Pharmacology. 53 (Suppl 1): 5S–12S. doi:10.1046/j.0306-5251.2001.00027.x. PMC 1874258 . PMID 11879254.

[AHFS2014-8] 8.0 ^8.1 ^8.2 ^8.3 "Sildenafil Citrate". The American Society of Health-System Pharmacists. 1 December 2014 khòaⁿ--ê.

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