Bián-e̍k kiám-cha-tiám
Bián-i̍k kiám-tsa-tiám (immune checkpoint) sī bián-i̍k hē-thóng ê tiâu-tsiat-khì. Tsia--ê tôo-kìng tuì tsū-ngóo nāi-siū tsì-kuan tiōng-iàu, ē-sái hông-tsí bián-i̍k hē-thóng bô-ka khu-pia̍t teh kong-kik sè-pau. M̄-kū, ū tsi̍t-kuá-á tsíng-liû ē-tàng thong-kuè tshì-kik bián-i̍k kiám-tsa-tiám tsit-ê bo̍k-piau lai pó-hōo ka-kī bián-siū kong-kik..[1]
Ap-tsè sìng kiám-tsa-tiám hun-tsú in-uī i teh tsiânn-tsē tsióng gâm-tsìng tang-tiong ê ìng-iōng tsiâm-li̍k in-tshú tsiânn-tsò gâm-tsìng bián-i̍k liâu-huat ê piau-pà. Bo̍k-tsiân phue-tsún ê kiám-tsa-tiám ap-tsè-tse ē-tàng tsóo-tn̄g CTLA4, PD-1 kah PD-L1. Pîng-tsiā siong-kuan khoh-ak ê huat-hiān, James P. Allison hām Tasuku Honjo îng-hi̍k 2018-nî sing-bu̍t tsè-io̍h kho-ha̍k Tông tsióng kah Nobel sing-li tsióng hi̍k-tsiá i-ha̍k tsióng.[2][3]
Tsham-khó bûn-hiàn[siu-kái | kái goân-sí-bé]
- ↑ Pardoll DM (March 2012). "The blockade of immune checkpoints in cancer immunotherapy". Nature Reviews. Cancer. 12 (4): 252–264. doi:10.1038/nrc3239. PMC 4856023
. PMID 22437870.
- ↑ "2014 Tang Prize in Biopharmaceutical Science". goân-loē-iông tī 2017-10-20 hőng khó͘-pih. 2016-06-18 khòaⁿ--ê.
- ↑ Devlin H (2018-10-01). "James P Allison and Tasuku Honjo win Nobel prize for medicine". the Guardian. 2018-10-01 khòaⁿ--ê.
Tsham-ua̍t[siu-kái | kái goân-sí-bé]
- CTLA4
- PD-1
- PD-L1